Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07WHS
|
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| Former ID |
DNC000443
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| Drug Name |
CL-316,243
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C20H20ClNO7
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| InChI |
InChI=1S/C20H20ClNO7/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27)/t11-,15+/m1/s1
|
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| InChIKey |
JEDJMKTVUPSHFW-ABAIWWIYSA-N
|
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| CAS Number |
CAS 138908-40-4
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Mitochondrial uncoupling protein 2 | Target Info | Inducer | [538030] | |
| Beta-3 adrenergic receptor | Target Info | Agonist | [535218] | ||
| Mitochondrial brown fat uncoupling protein 1 | Target Info | Inducer | [538030] | ||
| Mitochondrial uncoupling protein 3 | Target Info | Inducer | [538030] | ||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
| WikiPathways | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
| Electron Transport ChainWP58:Monoamine GPCRs | |||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP236:Adipogenesis | |||||
| Electron Transport ChainWP410:Diurnally Regulated Genes with Circadian Orthologs | |||||
| Electron Transport Chain | |||||
| References | |||||
| Ref 533802 | Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82. | ||||
| Ref 540400 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3462). | ||||
| Ref 535218 | Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans. Curr Pharm Des. 2001 Sep;7(14):1433-49. | ||||
| Ref 538030 | Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37. | ||||
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