Drug Information

Drug General Information
Drug ID
D08SNL
Former ID
DNC000828
Drug Name
JTC-801
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [539047], [547428]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C26H25N3O2
InChI
InChI=1S/C26H25N3O2/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30)
InChIKey
VTGBZWHPJFMTKS-UHFFFAOYSA-N
CAS Number
CAS 244218-51-7
PubChem Compound ID
5311340
PubChem Substance ID
15751745, 23941551, 26755045, 39341029, 57359442, 78782837, 85229982, 85787664, 103383609, 103992510, 114155865, 124892339, 129523706, 135650447, 136367909, 142094160, 144116096, 172113749, 185972815, 198975698, 202544347, 230798502
Target and Pathway
Target(s) Nociceptin receptor Target Info Antagonist [537331]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539047(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1692).
Ref 547428Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016171)
Ref 537331Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23(2):301-3. Epub 2009 May 15.

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