Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X4IA
|
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| Former ID |
DPR000045
|
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| Drug Name |
FK778
|
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| Synonyms |
Manitimus; FK 778; HMR 1715; MNA 715; Malononitrilamide 715; X 920715; FK-778; HMR-1715; MNA-715; MNA-X 920715; Malononitrilamide-715; X-920715; (2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxohept-6-ynenitrile; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynoic acid
|
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| Drug Type |
Small molecular drug
|
||||
| Indication | Kidney transplant rejection; Heart transplant rejection [ICD9: 996; ICD10:T86] | Discontinued in Phase 2 | [537129] | ||
| Company |
Astellas
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C15H11F3N2O2
|
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| CAS Number |
CAS 152418-67-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Dihydroorotate dehydrogenase | Target Info | Modulator | ||
| KEGG Pathway | Pyrimidine metabolism | ||||
| Metabolic pathways | |||||
| PANTHER Pathway | De novo pyrimidine ribonucleotides biosythesis | ||||
| PathWhiz Pathway | Pyrimidine Metabolism | ||||
| Reactome | Pyrimidine biosynthesis | ||||
| WikiPathways | Metabolism of nucleotides | ||||
| References | |||||
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