Drug General Information
Drug ID	D02UJD
Former ID	DIB001806
Drug Name	PD-143188
Synonyms	PD-147693; PD-149394; PD-155144; PD-163637; PD-163639
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Phase 2	[546028]
Company	Parke-Davis & Co
Structure		Download 2D MOL 3D MOL
Formula	C24H27N
Canonical SMILES	C1(=CCC[C@H](C1)CN1CC=C(CC1)c1ccccc1)c1ccccc1
CAS Number	CAS 150013-70-0
PubChem Compound ID	127698
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Modulator	[534559]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 546028	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005971)
Ref 534559	Anxiolytic effects of dopamine receptor ligands: I. Involvement of dopamine autoreceptors. Life Sci. 1998;62(7):649-63.

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