Drug General Information
Drug ID
D0F5VD
Former ID
DNCL003497
Drug Name
Ezatiostat
Synonyms
Telintra (TN)
Drug Type
Small molecular drug
Indication Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46] Phase 2 [523599]
Company
Telik
Structure
Download
2D MOL

3D MOL

Formula
C27H35N3O6S
Canonical SMILES
CCOC(=O)C(CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)<br />C(=O)OCC)N
InChI
1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChIKey
GWEJFLVSOGNLSS-WPFOTENUSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glutathione S-transferase P Target Info Modulator [550407]
BioCyc Pathway Glutathione-mediated detoxification
4-hydroxy-2-nonenal detoxification
KEGG Pathway Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Pathways in cancer
Chemical carcinogenesis
Prostate cancer
NetPath Pathway TCR Signaling Pathway
References
Ref 523599ClinicalTrials.gov (NCT01422486) Phase 2 Study of Telintra in Deletion 5q Myelodysplastic Syndrome. U.S. National Institutes of Health.
Ref 550407National Cancer Institute Drug Dictionary (drug id 485244).

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