Drug General Information
Drug ID	D0H3JF
Former ID	DNCL002201
Drug Name	VTX-2337
Drug Type	Small molecular drug
Indication	Allergy [ICD9: 995.3; ICD10:T78.4]		Discontinued in Phase 2	[524026]
Company	VentiRx Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C28H34N4O2
PubChem Compound ID	16049404
Target and Pathway
Target(s)	Toll-like receptor 8	Target Info	Modulator	[550276]
KEGG Pathway	Toll-like receptor signaling pathway
NetPath Pathway	Leptin Signaling Pathway
	TCR Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathway
Reactome	Trafficking and processing of endosomal TLR
	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
	MyD88 dependent cascade initiated on endosome
WikiPathways	Toll-like receptor signaling pathway
	Toll-Like Receptors Cascades
	MyD88 dependent cascade initiated on endosome
	Trafficking and processing of endosomal TLR
	Regulation of toll-like receptor signaling pathway
References
Ref 524026	ClinicalTrials.gov (NCT01666444) VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer. U.S. National Institutes of Health.
Ref 550276	Clinical pipeline report, company report or official report of Array BioPharma (Drug: Motolimod / VTX2337).

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