Drug Information

Drug General Information
Drug ID
D0J0ZQ
Former ID
DIB009751
Drug Name
Nociceptin/orphanin FQ receptor PET ligands
Synonyms
NOP receptor radioligands (neuropsychiatric disorders), Eli Lilly; Nociceptin/orphanin FQ receptor PET ligands (neuropsychiatric disorders); Nociceptin/orphanin FQ receptor PET ligands (neuropsychiatric disorders), Eli Lilly; 11C-NOP-1A
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Investigative [543766]
Company
Eli Lilly & Co
Structure
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2D MOL

3D MOL
Canonical SMILES
C12(CCN(CC1)C[C@@H](C(=O)N[11CH3])Cc1ccccc1F)OCCc1c2sc(<br />c1)F
Target and Pathway
Target(s) Nociceptin receptor Target Info Binder [543766]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).

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