Drug Information

Drug General Information
Drug ID
D0L8YY
Former ID
DIB016426
Drug Name
SR-14136
Synonyms
ORL1 ligands (pain); SR-14136; SR-14148; SR-14150; SR-14159; SR-16430; SR-16435; SR-16506; SR-16507; SR-16835; NOP receptor modulators (pain), SRI; ORL1 ligands (pain), SRI; Nociceptin/orphanin FQ modulators (pain), SRI
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [543766]
Company
SRI International
Structure
Download
2D MOL

3D MOL
Formula
C22H25N3O
Canonical SMILES
N1(C(=O)Cc2c1cccc2)C1CCN(CC1)C1CCCCCCC1
CAS Number
CAS 709024-69-1
PubChem Compound ID
10066285
Target and Pathway
Target(s) Nociceptin receptor Target Info Binder [543766]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).

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