Drug Information

Drug General Information
Drug ID
D0AC0A
Former ID
DIB000605
Drug Name
SB-612111
Synonyms
N/OFQ receptor antagonist (inflammatory disease), SRI International
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [539048]
Company
SRI International
Structure
Download
2D MOL

3D MOL
Formula
C24H29Cl2NO
InChI
InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3/t17-,23-/m0/s1
InChIKey
OHRDCQFCAWLDBP-SBUREZEXSA-N
CAS Number
CAS 371980-98-2
PubChem Compound ID
10047612
PubChem Substance ID
15031099, 22470182, 44164663, 49684226, 50074368, 74863525, 103683969, 135651011, 162223695, 174006859, 196376766, 210024101, 227317865, 242586566, 247008570
Target and Pathway
Target(s) Nociceptin receptor Target Info Antagonist [543766]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539048(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1693).
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).

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