Drug Information

Drug General Information
Drug ID
D0UI0B
Former ID
DIB000630
Drug Name
VTX-763
Synonyms
TLR-8 antagonist (autoimmune/inflammatory disease), VentiRx Pharmaceuticals
Indication Autoimmune diabetes [ICD10:E08-E13] Investigative [543476]
Company
VentiRx Pharmaceuticals Inc
Target and Pathway
Target(s) Toll-like receptor 8 Target Info Antagonist [543476]
KEGG Pathway Toll-like receptor signaling pathway
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 543476(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758).
Ref 543476(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758).

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