| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T88338 | ||||
| Target Name | 23S rRNA | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Linezolid | Drug Info | IC50 = 0.6 mcg/ml | [552342] | |
| Action against Disease Model | Macrolides | IC50 on translation in Staphylococcus aureus cells: 200 ng/mL | [552269] | Drug Info | |
| References | |||||
| Ref 552342 | Bacterial ribosomal subunit assembly is an antibiotic target. Curr Top Med Chem. 2003;3(9):929-47. | ||||
| Ref 552269 | A combination of roxithromycin and imipenem as an antimicrobial strategy against biofilms formed by Staphylococcus aureus. J Antimicrob Chemother. 2001 Oct;48(4):573-7. | ||||
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