| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T39087 | ||||
| Target Name | HIV integrase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Dolutegravir | Drug Info | IC50 = 0.51 nM | [552996] | |
| Action against Disease Model | Dolutegravir | GSK1349572 inhibited HIV integrase in an In vitro strand transfer assay. In PBMC cells, the antiviral EC50 and EC90 values were 0.51 and 2.0 nM, respectively. | Drug Info | ||
| References | |||||
| Ref 552996 | Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2010 Jan;54(1):254-8. doi: 10.1128/AAC.00842-09. Epub 2009 Nov 2. | ||||
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