Target Validation Information
Target ID T76914
Target Name Potassium voltage-gated channel subfamily A member 3
Target Type
Clinical Trial
Drug Potency against Target 1-Benzyl-7-chloro-4-hexyloxy-quinolinium Drug Info IC50 = 828 nM [533627]
Correloid Drug Info IC50 = 184 nM [527342]
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one Drug Info IC50 = 740 nM [531235]
5-(4-Phenylbutoxy)psoralen Drug Info IC50 = 724 nM [531233]
2-Methoxy-N-(3-methyl-2-phenyl-butyl)-benzamide Drug Info IC50 = 150 nM [526574]
[1-Benzyl-1H-quinolin-(4E)-ylidene]-hexyl-amine Drug Info IC50 = 1053 nM [533627]
CP-339818 Drug Info IC50 = 230 nM [526035]
UK-78282 Drug Info IC50 = 280 nM [526035]
References
Ref 533627J Med Chem. 1995 May 26;38(11):1877-83.Novel inhibitors of potassium ion channels on human T lymphocytes.
Ref 527342Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51.Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Ref 531235Bioorg Med Chem Lett. 2010 Dec 1;20(23):6989-92. Epub 2010 Oct 23.Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.
Ref 531233Bioorg Med Chem Lett. 2010 Dec 1;20(23):6983-8. Epub 2010 Oct 7.N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1.
Ref 526574Bioorg Med Chem Lett. 2003 Mar 24;13(6):1161-4.Benzamide derivatives as blockers of Kv1.3 ion channel.
Ref 533627J Med Chem. 1995 May 26;38(11):1877-83.Novel inhibitors of potassium ion channels on human T lymphocytes.
Ref 526035J Med Chem. 2001 Apr 12;44(8):1249-56.Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.
Ref 526035J Med Chem. 2001 Apr 12;44(8):1249-56.Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.

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