| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T95139 | ||||
| Target Name | Cysteine protease | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | S-isopentyl 3-methylbutane-1-sulfinothioate | Drug Info | Ki = 360 nM | [531093] | |
| S-benzyl phenylmethanesulfinothioate | Drug Info | Ki = 2310 nM | [531093] | ||
| ALLICIN | Drug Info | Ki = 5310 nM | [531093] | ||
| S-propyl propane-1-sulfinothioate | Drug Info | Ki = 4440 nM | [531093] | ||
| S-hexyl hexane-1-sulfinothioate | Drug Info | Ki = 1000 nM | [531093] | ||
| K-777 | Drug Info | IC50 = 7 nM | [530398] | ||
| References | |||||
| Ref 531093 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. | ||||
| Ref 531093 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. | ||||
| Ref 531093 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. | ||||
| Ref 531093 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. | ||||
| Ref 531093 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. | ||||
| Ref 530398 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. Epub 2009 Sep 3.Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. | ||||
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