Target Validation Information
Target ID T26617
Target Name Lactase-phlorizin hydrolase
Target Type
Drug Potency against Target 2,5-dideoxy-2,5-imino-dl-glycero-D-manno-heptitol Drug Info IC50 = 4000 nM [534633]
Hyacinthacine B3 Drug Info IC50 = 18000 nM [526494]
2,5-dideoxy-2,5-imino-D-altritol Drug Info IC50 = 7200 nM [530905]
Ref 534633J Nat Prod. 1998 May;61(5):625-8.Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis.
Ref 526494J Nat Prod. 2002 Dec;65(12):1875-81.New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica.
Ref 530905Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. Epub 2010 Apr 21.2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease.

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