Target Validation Information
Target ID T78393
Target Name mRNA of human Macrophage migration inhibitory factor
Target Type
Research
Drug Potency against Target S-benzo[d]oxazol-2-yl O-butyl carbonothioate Drug Info IC50 = 150 nM
3-(1H-pyrazol-3-yl)benzoic acid Drug Info IC50 = 15000 nM [529867]
Benzofuran-2-yl(indolin-1-yl)methanone Drug Info IC50 = 4000 nM [529867]
2-(4-hydroxystyryl)quinolin-8-ol Drug Info IC50 = 8000 nM [529867]
3-benzyl-6-methylbenzo[d]oxazol-2(3H)-one Drug Info IC50 = 3400 nM [531118]
1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea Drug Info IC50 = 1010 nM
4-(4-benzyl-1H-1,2,3-triazol-1-yl)phenol Drug Info IC50 = 3500 nM [531232]
1-phenyl-3-(1,3,4-thiadiazol-2-yl)thiourea Drug Info IC50 = 420 nM
6-phenylpyridazin-3-yl thiophene-2-carboxylate Drug Info IC50 = 50 nM
3-acetyl-7-hydroxy-2H-chromen-2-one Drug Info Ki = 4300 nM [529867]
7-hydroxy-3-phenyl-2H-chromen-2-one Drug Info Ki = 470 nM [529867]
N-(2-bromobenzoyloxy)-4-chlorobenzamide Drug Info IC50 = 4200 nM
Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate Drug Info Ki = 7400 nM [529867]
4-((pyridin-4-ylthio)methyl)benzene-1,2-diol Drug Info IC50 = 400 nM [527973]
3,3,3-tris(4-chlorophenyl)propanoic acid Drug Info IC50 = 8100 nM [527973]
3-benzyl-5-methylbenzo[d]oxazol-2(3H)-one Drug Info IC50 = 1500 nM [531118]
3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one Drug Info IC50 = 1000 nM [531118]
References
Ref 529867J Med Chem. 2009 Jan 22;52(2):416-24.Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Ref 529867J Med Chem. 2009 Jan 22;52(2):416-24.Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Ref 529867J Med Chem. 2009 Jan 22;52(2):416-24.Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Ref 531118Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. Epub 2010 Aug 3.Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).
Ref 531232Bioorg Med Chem Lett. 2010 Dec 1;20(23):7033-6. Epub 2010 Sep 29.Receptor agonists of macrophage migration inhibitory factor.
Ref 529867J Med Chem. 2009 Jan 22;52(2):416-24.Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Ref 529867J Med Chem. 2009 Jan 22;52(2):416-24.Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Ref 529867J Med Chem. 2009 Jan 22;52(2):416-24.Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Ref 527973J Med Chem. 2006 Jan 26;49(2):523-33.Classification of chemical compounds by protein-compound docking for use in designing a focused library.
Ref 527973J Med Chem. 2006 Jan 26;49(2):523-33.Classification of chemical compounds by protein-compound docking for use in designing a focused library.
Ref 531118Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. Epub 2010 Aug 3.Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).
Ref 531118Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. Epub 2010 Aug 3.Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).

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