Target Information

Target General Infomation
Target ID
T07063
Former ID
TTDR01001
Target Name
Sodium/iodide cotransporter
Gene Name
SLC5A5
Synonyms
NIS; Na(+)/I(-) cotransporter; Na+/I-symporter; Sodium-iodide symporter; Sodium/iodide symporter; SLC5A5
Target Type
Clinical Trial
Disease Prostate cancer [ICD9: 185; ICD10: C61]
Function
Mediates iodide uptake in the thyroid gland.
BioChemical Class
Solute:sodium symporter
UniProt ID
Q92911
Sequence
MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVG
LSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEY
LEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTA
VGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRS
RYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCG
IVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSIN
AMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVM
GVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSA
ARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTV
LCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKK
PPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL
Drugs and Mode of Action
Drug(s) Ad5CMV-NIS Drug Info Phase 1 Prostate cancer [522479]
Modulator Ad5CMV-NIS Drug Info [544120]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 522479ClinicalTrials.gov (NCT00788307) Gene Therapy and Radioactive Iodine in Treating Patients With Locally Recurrent Prostate Cancer That Did Not Respond to External-Beam Radiation Therapy. U.S. NationalInstitutes of Health.
Ref 544120Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter. Mol Ther. 2009 December; 17(12): 2041-2048.

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