Target Information

Target General Infomation
Target ID
T14676
Former ID
TTDNC00650
Target Name
APRIL
Gene Name
TNFSF13
Synonyms
A proliferation-inducing ligand; CD256; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TRDL-1; Tumor necrosis factor ligand superfamily member 13; TNFSF13
Target Type
Clinical Trial
Disease Lymphoma; Graft rejection in heart transplantation; Idiopathic thrombocytopenic purpura [ICD9:202.8, 208.9, 287.31, 996; ICD10: C81-C86, D69.3, T86]
Rheumatold arthritis; Multiple sclerosis [ICD9: 340, 710-719, 714; ICD10: G35, M00-M25, M05-M06]
Function
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
BioChemical Class
Cytokine: tumor necrosis factor
UniProt ID
O75888
Sequence
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
HGTFLGFVKL
Drugs and Mode of Action
Drug(s) Atacicept Drug Info Phase 3 Lymphoma; Graft rejection in heart transplantation; Idiopathic thrombocytopenic purpura [530405], [537129]
Atacicept Drug Info Phase 2 Rheumatold arthritis; Multiple sclerosis [537129]
Modulator Atacicept Drug Info [530405]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 530405Atacicept: a new B lymphocyte-targeted therapy for multiple sclerosis. Nervenarzt. 2009 Dec;80(12):1462-72.
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 530405Atacicept: a new B lymphocyte-targeted therapy for multiple sclerosis. Nervenarzt. 2009 Dec;80(12):1462-72.

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