Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T20808
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| Former ID |
TTDI02095
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| Target Name |
Isocitrate dehydrogenase (IDH2)
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| Gene Name |
IDH2
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| Synonyms |
ICDM; IDH; IDP; Isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)specific ICDH; Oxalosuccinate decarboxylase; IDH2
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| Target Type |
Clinical Trial
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| Disease | Acute myeloid leukemia [ICD9: 205; ICD10: C92.0] | ||||
| Function |
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
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| BioChemical Class |
Short-chain dehydrogenases reductases
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| UniProt ID | |||||
| EC Number |
EC 1.1.1.42
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| Sequence |
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Citrate cycle (TCA cycle) | ||||
| Glutathione metabolism | |||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| Carbon metabolism | |||||
| 2-Oxocarboxylic acid metabolism | |||||
| Biosynthesis of amino acids | |||||
| Peroxisome | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| WikiPathways | TCA Cycle | ||||
| The citric acid (TCA) cycle and respiratory electron transport | |||||
| References | |||||
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