Target Information

Target General Infomation
Target ID
T28998
Former ID
TTDS00253
Target Name
Gonadotropin-releasing hormone
Gene Name
GNRH1
Synonyms
GnRH; Gonadoliberin; LH-RH; LHRH; Leutinizing-hormone-releasing hormone; Luliberin; GNRH1
Target Type
Clinical Trial
Disease Prostate cancer [ICD9: 185; ICD10: C61]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
BioChemical Class
Hormone
Target Validation
T28998
UniProt ID
P01148
Sequence
MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQR
FECTTHQPRSPLRDLKGALESLIEEETGQKKI
Drugs and Mode of Action
Drug(s) CG201 Drug Info Phase 2 Solid tumours [547378]
Norelin Drug Info Discontinued in Phase 2 Prostate cancer [546966]
Inhibitor Anti-GnRH Spiegelmer Drug Info [535483]
Norelin Drug Info [546967]
Modulator CG201 Drug Info [1572591]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway GnRH signaling pathway
Pathway Interaction Database Nongenotropic Androgen signaling
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 546966Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011623)
Ref 547378Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015700)
Ref
Ref 535483In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8898-902. Epub 2002 Jun 17.
Ref 546967Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011623)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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