Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T37735
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| Former ID |
TTDI02082
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| Target Name |
Glutamate decarboxylase
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| Gene Name |
GLUL
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| Synonyms |
GS; Glutamateammonia ligase; Glutamine synthetase; GLUL
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| Target Type |
Discontinued
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| Disease | Parkinson's disease [ICD9: 332; ICD10: G20] | ||||
| Function |
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
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| BioChemical Class |
Carbon-nitrogen ligase
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| UniProt ID | |||||
| EC Number |
EC 4.1.1.15
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| Sequence |
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL LNETGDEPFQYKN |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Glutamate dependent acid resistance | ||||
| GABA shunt | |||||
| Glutamine biosynthesis | |||||
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | ||||
| Arginine and proline metabolism | |||||
| Glyoxylate and dicarboxylate metabolism | |||||
| Nitrogen metabolism | |||||
| Metabolic pathways | |||||
| Biosynthesis of amino acids | |||||
| Glutamatergic synapse | |||||
| GABAergic synapse | |||||
| PANTHER Pathway | Glutamine glutamate conversion | ||||
| Reactome | Amino acid synthesis and interconversion (transamination) | ||||
| WikiPathways | Metabolism of amino acids and derivatives | ||||
| TNF alpha Signaling Pathway | |||||
| Neurotransmitter uptake and Metabolism In Glial Cells | |||||
| References | |||||
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