Target Information

Target General Infomation
Target ID
T48940
Target Name
HIF prolyl hydroxylase
Target Type
Successful
Disease Anemia [ICD9: 280-285; ICD10: D50-D64]
Anemia; Kidney disease [ICD9: 280-285, 580-589; ICD10: D50-D64, N00-N29]
Fungal infections [ICD9: 110-118; ICD10: B35-B49]
BioChemical Class
Oxidoreductases (EC:1)
EC Number
EC 1.14.11.29
Drugs and Mode of Action
Drug(s) Ciclopirox Drug Info Approved Fungal infections [538315]
AKB-6548 Drug Info Phase 2 Anemia [523526]
FG-2216 Drug Info Phase 2 Anemia; Kidney disease [547665]
DS-1093 Drug Info Phase 1 Anemia [525009]
JTZ-951 Drug Info Phase 1 Anemia [524512]
Modulator AKB-6548 Drug Info
Ciclopirox Drug Info [556264]
DS-1093 Drug Info
FG-2216 Drug Info
JTZ-951 Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 523526ClinicalTrials.gov (NCT01381094) 42-Day Repeat Oral Dose Study of AKB-6548 in Subjects With Chronic Kidney Disease and Anemia. U.S. National Institutes of Health.
Ref 524512ClinicalTrials.gov (NCT01978587) Effect of Hemodialysis on the PK of JTZ-951 in Subjects With End-stage Renal Disease. U.S. National Institutes of Health.
Ref 525009ClinicalTrials.gov (NCT02299661) Pilot PK/PD Study of DS-1093a in Patients With Chronic Kidney Disease. U.S. National Institutes of Health.
Ref 538315FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076435.
Ref 547665Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018242)
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.