Target Information

Target General Infomation
Target ID
T51223
Former ID
TTDNC00371
Target Name
IL-21
Gene Name
IL21
Synonyms
Interleukin21; Za11; IL21
Target Type
Clinical Trial
Disease Autoimmune diabetes [ICD10: E08-E13]
Colorectal cancer [ICD9: 153, 154; ICD10: C18-C21]
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cellsin synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
BioChemical Class
Cytokine: interleukin
UniProt ID
Q9HBE4
Sequence
MERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDV
ETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDS
YEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
Drugs and Mode of Action
Drug(s) IL-21 Drug Info Phase 2 Colorectal cancer [468116], [523093]
NN-8828 Drug Info Phase 1 Autoimmune diabetes [523183]
Modulator IL-21 Drug Info [550398]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Inflammatory bowel disease (IBD)
PANTHER Pathway Interleukin signaling pathway
WikiPathways Allograft Rejection
References
Ref 468116(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4987).
Ref 523093ClinicalTrials.gov (NCT01152788) Phase II Study of Interleukin-21 (rIL-21) vs Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma. U.S. National Institutes of Health.
Ref 523183ClinicalTrials.gov (NCT01208506) First-in-Man Trial of NNC114-0005 in Healthy Subjects and Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 550398National Cancer Institute Drug Dictionary (drug id 409696).
Ref 551834Handbook of Therapeutic Antibodies. 2014. 1. Page(995).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.