Target Information

Target General Infomation
Target ID
T65291
Former ID
TTDS00053
Target Name
Aldehyde dehydrogenase
Gene Name
ALDH3A2
Synonyms
ALDH3A2
Target Type
Successful
Disease Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Epilepsy [ICD10: G40]
BioChemical Class
Oxidoreductases acting on aldehyde or oxo group of donors
Target Validation
T65291
UniProt ID
P51648
EC Number
EC 1.2.1.8
Sequence
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY
Drugs and Mode of Action
Drug(s) Disulfiram Drug Info Approved Alcohol use disorders [536276], [542177]
NPS 1776 Drug Info Discontinued in Phase 2 Epilepsy [546901]
Inhibitor Aloe-emodin Drug Info [551367]
Disulfiram Drug Info [536206]
NSC-527035 Drug Info [530782]
S-methyl 4-methyl-4-morpholinopent-2-ynethioate Drug Info [528983]
Modulator NPS 1776 Drug Info [544010]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 536276Choosing the right medication for the treatment of alcoholism. Curr Psychiatry Rep. 2006 Oct;8(5):383-8.
Ref 542177(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7168).
Ref 546901Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010984)
Ref 528983Eur J Med Chem. 2008 May;43(5):906-16. Epub 2007 Jul 6.Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture.
Ref 530782J Med Chem. 2010 Apr 8;53(7):2757-65.Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.
Ref 536206Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther. 2006 Sep;111(3):855-76. Epub 2006 Mar 20.
Ref 544010Diverse Mechanisms of Antiepileptic Drugs in the Development Pipeline. Epilepsy Res. 2006 June; 69(3): 273-294.
Ref 551367Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens J. Nat. Prod. 60(11):1180-1182 (1997).

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