Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T67207
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| Former ID |
TTDI02068
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| Target Name |
Fc-epsilon-RII (CD23)
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| Gene Name |
FCER2
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| Synonyms |
BLAST2; CD23; Ctype lectin domain family 4 member J; FcepsilonRII; Immunoglobulin Ebinding factor; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor soluble form; Lymphocyte IgE receptor; FCER2
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| Target Type |
Clinical Trial
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| Disease | Leukemia [ICD9: 208.9; ICD10: C90-C95] | ||||
| Function |
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
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| BioChemical Class |
Immunoglobulin
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| UniProt ID | |||||
| Sequence |
MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERA
ARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADL SSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKG TKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHV DYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESM GPDSRPDPDGRLPTPSAPLHS |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Hematopoietic cell lineage | ||||
| Epstein-Barr virus infection | |||||
| NetPath Pathway | IL-7 Signaling Pathway | ||||
| IL3 Signaling Pathway | |||||
| IL4 Signaling Pathway | |||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| Reactome | NOTCH2 intracellular domain regulates transcription | ||||
| WikiPathways | Human Complement System | ||||
| Signaling by NOTCH2 | |||||
| References | |||||
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