Target Information

Target General Infomation
Target ID
T70518
Former ID
TTDI02232
Target Name
S-nitrosoglutathione reductase
Gene Name
CBR1
Synonyms
15hydroxyprostaglandin dehydrogenase [NADP(+)]; Carbonyl reductase [NADPH] 1; NADPHdependent carbonyl reductase 1; Prostaglandin 9ketoreductase; ProstaglandinE(2) 9reductase; CBR1
Target Type
Clinical Trial
Disease Asthma [ICD10: J45]
Function
NADPH-dependent reductase with broad substratespecificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
BioChemical Class
Short-chain dehydrogenases reductases
UniProt ID
P16152
EC Number
EC 1.1.1.189
Sequence
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
Drugs and Mode of Action
Drug(s) N6022 Drug Info Phase 2 Asthma [531801]
Inhibitor N6022 Drug Info [531801]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 531801Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51(10):2157-68.
Ref 531801Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51(10):2157-68.

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