Target Information

Target General Infomation
Target ID
T79160
Former ID
TTDI02527
Target Name
Glial cell neurotrophic factor ligand
Gene Name
GDNF
Synonyms
ATF; Astrocytederived trophic factor; Glial cell linederived neurotrophic factor; hGDNF; GDNF
Target Type
Clinical Trial
Disease Lateral sclerosis [ICD10: G12.2]
Function
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.
BioChemical Class
Transforming growth factor
UniProt ID
P39905
Sequence
MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
Drugs and Mode of Action
Drug(s) Liatermin Drug Info Phase 1/2 Lateral sclerosis [521642]
Modulator Liatermin Drug Info [1572591]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 521642ClinicalTrials.gov (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
Ref
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.