Target Information

Target General Infomation
Target ID
T86264
Former ID
TTDNC00532
Target Name
Ferroportin
Gene Name
SLC40A1
Synonyms
Ferroportin-1; Iron-regulated transporter 1; Solute carrier family 40 member 1; SLC40A1
Target Type
Clinical Trial
Disease Anemia [ICD9: 280-285; ICD10: D50-D64]
Function
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
BioChemical Class
Ferroportin family
UniProt ID
Q9NP59
Sequence
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLL
TAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHEL
LTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRI
DQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLK
EEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWV
SYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAF
TWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITP
TKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLL
QENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFR
FAQNTLGNKLFACGPDAKEVRKENQANTSVV
Drugs and Mode of Action
Drug(s) Ferroportin mab Drug Info Phase 1 Anemia [524538]
LY2928057 Drug Info Phase 1 Anemia [523421]
Modulator LY2928057 Drug Info [544308]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
DRM DRM Info
Pathways
KEGG Pathway Mineral absorption
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome Iron uptake and transport
WikiPathways Iron uptake and transport
Iron metabolism in placenta
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 523421ClinicalTrials.gov (NCT01330953) A First Human Study of a Ferroportin Antibody. U.S. National Institutes of Health.
Ref 524538ClinicalTrials.gov (NCT01991483) A Study of LY2928057 in Hemodialysis Participants. U.S. National Institutes of Health.
Ref 544308Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation. Am J Hematol. 2012 April; 87(4): 392-400.
Ref 544389The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161.

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