Target Information

Target General Infomation
Target ID
T88452
Former ID
TTDS00068
Target Name
Corticosteroid-binding globulin
Gene Name
SERPINA6
Synonyms
CBG; Transcortin; SERPINA6
Target Type
Successful
Disease Asthma; Obstructive airway diseases [ICD9:490-492, 494-496; ICD10: J45, J40-J44, J47]
Diabetic macular edema [ICD9: 250, 362.01, 362.07, 362.53, 782.3; ICD10: E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9]
Diabetic retinopathy [ICD9: 250.5; ICD10: H36, E10.3, E11.3, E13.3]
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25]
Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
BioChemical Class
Serpin family
Target Validation
T88452
UniProt ID
P08185
Sequence
MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPK
KNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSD
TSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQG
KIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTI
SYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLY
IPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDT
AGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
Drugs and Mode of Action
Drug(s) Alclometasone Drug Info Approved Inflammatory disease [536361]
Ciclesonide Drug Info Approved Asthma; Obstructive airway diseases [528715], [536958], [542493], [551871]
Paramethasone Drug Info Approved Inflammatory disease [538461]
Paramethasone Drug Info Phase 3 Diabetic macular edema [551871]
I-vation Drug Info Phase 2 Diabetic retinopathy [532534]
Binder Alclometasone Drug Info [537683]
Ciclesonide Drug Info [534951], [535929]
Paramethasone Drug Info [534951], [535929]
Modulator I-vation Drug Info [527905]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 5287152006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
Ref 532534Drug delivery implants in the treatment of vitreous inflammation. Mediators Inflamm. 2013;2013:780634.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 536958Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
Ref 538461FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012772.
Ref 542493(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7469).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527905Cortisol binding in rat skeletal muscle. J Biol Chem. 1975 Feb 25;250(4):1207-11.
Ref 534951Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Metab. 2000 Jan;85(1):361-7.
Ref 535929A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol. J Steroid Biochem Mol Biol. 1992 Aug;42(7):671-6.
Ref 537683The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2.

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