Target Information

Target General Infomation
Target ID
T98052
Former ID
TTDI02305
Target Name
SLAM family member 7 (SLAMF7) (CS1)
Gene Name
SLAMF7
Synonyms
CD2 subset 1; CD2-like receptor-activating cytotoxic cells; CD319; CRACC; Membrane protein FOAP-12; Novel Ly9; Protein 19A; SLAMF7
Target Type
Clinical Trial
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Multiple myeloma [ICD9: 203; ICD10: C90]
Function
Isoform 3 does not mediate any NK cell activation.
BioChemical Class
Immunoglobulin
UniProt ID
Q9NQ25
Sequence
MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPL
VTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEY
VLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSIL
PISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMVLLCLLLVPLLLSL
FVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICPHSGENTEYDTIPHTNRTILKEDPA
NTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENVI
Drugs and Mode of Action
Drug(s) Elotuzumab Drug Info Approved Multiple myeloma [523429], [543087]
PVX-410 Drug Info Phase 1 Cancer [524108]
Modulator PVX-410 Drug Info [530353], [533177]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 523429ClinicalTrials.gov (NCT01335399) Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Newly Diagnosed, Previously Untreated Multiple Myeloma. U.S. National Institutesof Health.
Ref 524108ClinicalTrials.gov (NCT01718899) Phase 1/2a Study of Cancer Vaccine to Treat Smoldering Multiple Myeloma. U.S. National Institutes of Health.
Ref 543087(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8361).
Ref 530353Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma. Mol Cancer Ther. 2009 Sep;8(9):2616-24.
Ref 533177Market watch: Upcoming catalysts in Q2 2015. Nat Rev Drug Discov. 2015 Apr;14(4):228.

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