Target Information

Target General Infomation
Target ID
T16792
Former ID
TTDS00426
Target Name
Type I iodothyronine deiodinase
Gene Name
DIO1
Synonyms
5DI; DIOI; ITDI1; TXDI1; Type 1 DI; Type-I 5'-deiodinase; DIO1
Target Type
Successful
Disease Hyperthyroidism; Alcoholic hepatitis [ICD9:242, 571.1; ICD10: E05, K70.1]
BioChemical Class
Thyroxine 5'-deiodinase
UniProt ID
P49895
EC Number
EC 1.97.1.10
Sequence
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
RAVLEKLHS
Drugs and Mode of Action
Drug(s) Propylthiouracil Drug Info Approved Hyperthyroidism; Alcoholic hepatitis [538392], [541761], [551871]
Inhibitor Propylthiouracil Drug Info [536479]
Pathways
BioCyc Pathway Thyronamine and iodothyronamine metabolism
Thyroid hormone metabolism II (via conjugation and/or degradation)
Thyroid hormone metabolism I (via deiodination)
KEGG Pathway Thyroid hormone signaling pathway
WikiPathways Selenium Metabolism and Selenoproteins
Metabolism of amino acids and derivatives
Selenium Micronutrient Network
References
Ref 538392FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 006188.
Ref 541761(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6650).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536479Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):740-1. Epub 2007 Aug 21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.