Target Information

Target General Infomation
Target ID
T20578
Former ID
TTDI01952
Target Name
Phosphodiesterase (PDE) 7B
Gene Name
PDE7B
Synonyms
cAMPspecific 3',5'cyclic phosphodiesterase 7B; PDE7B
Target Type
Discontinued
Disease Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
BioChemical Class
Phosphoric diester hydrolases
UniProt ID
Q9NP56
EC Number
EC 3.1.4.17
Sequence
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
Structure
1ZKL; 3G3N; 4PM0; 1LXW
Drugs and Mode of Action
Drug(s) PF-3557156 Drug Info Discontinued in Phase 1 Pain [548590]
Inhibitor BRL50481 Drug Info [530787]
SCH51866 Drug Info [525769]
Modulator PF-3557156 Drug Info
Pathways
KEGG Pathway Purine metabolism
Morphine addiction
Reactome G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
References
Ref 548590Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026842)
Ref 525769Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83.
Ref 530787New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen. 2010 Apr;15(4):359-67.

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