Drug Information

Drug General Information
Drug ID
D02VHD
Former ID
DIB020929
Drug Name
SCH51866
Synonyms
SCH 51866; SCH-51866
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540734]
Structure
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2D MOL

3D MOL
Formula
C19H18F3N5O
InChI
InChI=1S/C19H18F3N5O/c1-26-17(28)15-16(27-13-4-2-3-12(13)23-18(26)27)25-14(24-15)9-10-5-7-11(8-6-10)19(20,21)22/h5-8,12-13H,2-4,9H2,1H3,(H,24,25)/t12-,13+/m1/s1
InChIKey
JOSMPBVYYKRYLG-OLZOCXBDSA-N
PubChem Compound ID
15473392
PubChem Substance ID
124958915, 128305491, 128305492, 135653859, 175427545, 178101953, 198988510, 223795388, 226760398
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [534290]
PDE1A Target Info Inhibitor [534290]
Phosphodiesterase (PDE) 1B Target Info Inhibitor [534290]
Phosphodiesterase (PDE) 7B Target Info Inhibitor [525769]
PDE1C Target Info Inhibitor [534290]
Phosphodiesterase (PDE) 9 Target Info Inhibitor [534647]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathwayhsa00230:Purine metabolism
Calcium signaling pathway
Morphine addictionhsa00230:Purine metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Regulation of Androgen receptor activity
Reactome cGMP effectsR-HSA-418457:cGMP effects
G alpha (s) signalling eventsR-HSA-418555:G alpha (s) signalling eventsR-HSA-418457:cGMP effects
WikiPathways G Protein Signaling Pathways
DAG and IP3 signaling
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 540734(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5270).
Ref 525769Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83.
Ref 534290Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9.
Ref 534647Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64.

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