Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T77613
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| Former ID |
TTDI02454
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| Target Name |
Phosphodiesterase (PDE) 1B
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| Gene Name |
PDE1B
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| Synonyms |
63 kDa CamPDE; Calcium/calmodulindependent 3',5'cyclicnucleotide phosphodiesterase 1B; CamPDE 1B; PDE1B
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| Target Type |
Research
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| Disease | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3] | ||||
| Function |
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
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| BioChemical Class |
Phosphoric diester hydrolases
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| UniProt ID | |||||
| EC Number |
EC 3.1.4.17
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| Sequence |
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD |
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| Pathways | |||||
| KEGG Pathway | Purine metabolism | ||||
| Calcium signaling pathway | |||||
| Morphine addiction | |||||
| Reactome | cGMP effects | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | G Protein Signaling Pathways | ||||
| DAG and IP3 signaling | |||||
| Opioid Signalling | |||||
| References | |||||
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