Target Information

Target General Infomation
Target ID
T28226
Former ID
TTDR00115
Target Name
GTP cyclohydrolase I
Gene Name
GCH1
Synonyms
GTP-CH-I; Guanosine triphosphate cyclohydrolase I; GCH1
Target Type
Clinical Trial
Disease Parkinson's disease [ICD9: 332; ICD10: G20]
Function
Isoform gch-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
P30793
EC Number
EC 3.5.4.16
Sequence
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRS
EEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDA
IFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQ
VQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKT
REEFLTLIRS
Structure
1FB1
Drugs and Mode of Action
Drug(s) Guanine Drug Info Phase 3 Discovery agent [467793], [521421]
ProSavin Drug Info Phase 1/2 Parkinson's disease [524296]
Inhibitor 8-hydroxyguanine Drug Info [535179]
Guanine Drug Info [535179]
Guanosine-5'-Triphosphate Drug Info [551393]
Isopropyl Alcohol Drug Info [551374]
Modulator ProSavin Drug Info [551478]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
PathWhiz Pathway Pterine Biosynthesis
Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
References
Ref 467793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4556).
Ref 521421ClinicalTrials.gov (NCT00001100) A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections.. U.S. National Institutes of Health.
Ref 524296ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health.
Ref 535179GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551478Clinical pipeline report, company report or official report of Oxford BioMedica.

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