Target Information

Target General Infomation
Target ID
T34318
Former ID
TTDNS00564
Target Name
Cathelicidin antimicrobial peptide
Gene Name
CAMP
Synonyms
18 kDa cationic antimicrobial protein; Antibacterial protein LL37; CAP18; Cathelicidin antimicrobial peptide; hCAP18; upregulating cAMP; CAMP
Target Type
Successful
Disease Asthma [ICD10: J45]
Function
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
BioChemical Class
Cathelicidin family
UniProt ID
P49913
Sequence
MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLLD
LDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGS
FDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Structure
2FBS; 2FBU; 2FCG; 2K6O; 2LMF; 4EYC
Drugs and Mode of Action
Drug(s) Colforsin daropate hci Drug Info Approved Asthma [526492]
Colforsin daropate hci Drug Info Terminated Discovery agent [544574]
Modulator Colforsin daropate hci Drug Info [527499], [536361]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Salivary secretion
Tuberculosis
Reactome ROS production in response to bacteria
WikiPathways Vitamin D Receptor Pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis
Integrated Pancreatic Cancer Pathway
SREBP signalling
References
Ref 526492Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine. Circ J. 2002 Dec;66(12):1150-4.
Ref 544574Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000192)
Ref 527499Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep. 2005 Apr;22(2):162-95. Epub 2005 Mar 8.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.

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