Target Information

Target General Infomation
Target ID
T66290
Former ID
TTDI01717
Target Name
L-type calcium channel
Target Type
Successful
Disease Angina pectoris [ICD9: 413; ICD10: I20]
Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F31, F40-F42]
Cardiovascular disorder [ICD10: I00-I99]
Dementia [ICD9: 290-294; ICD10: F01-F07]
Hypertension [ICD9: 401; ICD10: I10-I16]
Nerve injury [ICD10: T14.4]
Drugs and Mode of Action
Drug(s) Nifedipine Drug Info Approved Angina pectoris [535549], [539636]
Levamlodipine Drug Info Phase 4 Hypertension [523057], [532021]
MEM-1003 Drug Info Phase 2a Bipolar disorder [536295]
BAY-Y-5959 Drug Info Phase 2 Cardiovascular disorder [545794]
MEM-1003 Drug Info Phase 2 Dementia [528140]
Furnidipine Drug Info Discontinued in Phase 3 Nerve injury [545239]
Modulator BAY-Y-5959 Drug Info [534680]
Furnidipine Drug Info
Levamlodipine Drug Info [529585]
MEM-1003 Drug Info [528140]
Nifedipine Drug Info [556264]
References
Ref 523057ClinicalTrials.gov (NCT01131546) Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension. U.S. National Institutes of Health.
Ref 528140Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits. Neurobiol Aging. 2007 May;28(5):766-73. Epub 2006 Apr 18.
Ref 532021Quantification of pedal edema during treatment with S(-)-amlodipine nicotinate versus amlodipine besylate in female Korean patients with mild to moderate hypertension: a 12-week, multicenter, randomized, double-blind, active-controlled, phase IV clinical trial. Clin Ther. 2012 Sep;34(9):1940-7.
Ref 535549Are sildenafil and theophylline effective in the prevention of high-altitude pulmonary edema? Med Hypotheses. 2002 Aug;59(2):223-5.
Ref 536295Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34.
Ref 539636(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2514).
Ref 545239Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002558)
Ref 545794Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004756)
Ref 528140Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits. Neurobiol Aging. 2007 May;28(5):766-73. Epub 2006 Apr 18.
Ref 529585Effects of (S)-amlodipine and (R)-amlodipine on L-type calcium channel current of rat ventricular myocytes and cytosolic calcium of aortic smooth muscle cells. Pharmazie. 2008 Jun;63(6):470-4.
Ref 534680Hemodynamic effects of a calcium channel promoter, BAY y 5959, are preserved after chronic administration in ischemic heart failure in conscious dogs. J Pharmacol Exp Ther. 1998 Aug;286(2):760-6.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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