Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T67658
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| Former ID |
TTDR00776
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| Target Name |
Solute carrier family 2, facilitated glucose transporter, member 4
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| Gene Name |
SLC2A4
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| Synonyms |
Glucose transporter type 4, insulin-responsive; Glut4 protein; SLC2A4
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| Target Type |
Clinical Trial
|
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| Disease | Type 2 diabetes [ICD9: 250; ICD10: E11] | ||||
| Function |
Insulin-regulated facilitative glucose transporter.
|
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| BioChemical Class |
Major facilitator superfamily
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| UniProt ID | |||||
| Sequence |
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETW
LGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAV LGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI VIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPA RKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQL SGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGM CGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM AVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQIS AAFHRTPSLLEQEVKPSTELEYLGPDEND |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | FoxO signaling pathway | ||||
| AMPK signaling pathway | |||||
| Insulin signaling pathway | |||||
| Adipocytokine signaling pathway | |||||
| Type II diabetes mellitus | |||||
| Pathway Interaction Database | Arf6 trafficking events | ||||
| Insulin-mediated glucose transport | |||||
| Class I PI3K signaling events mediated by Akt | |||||
| PathWhiz Pathway | Glucose-Alanine Cycle | ||||
| Insulin Signalling | |||||
| Reactome | Translocation of GLUT4 to the plasma membrane | ||||
| Transcriptional regulation of white adipocyte differentiation | |||||
| Facilitative Na+-independent glucose transporters | |||||
| Glucose transport | |||||
| WikiPathways | Glycolysis and Gluconeogenesis | ||||
| Insulin Signaling | |||||
| NRF2 pathway | |||||
| Vitamin D Receptor Pathway | |||||
| Translocation of GLUT4 to the Plasma Membrane | |||||
| Transcriptional Regulation of White Adipocyte Differentiation | |||||
| Adipogenesis | |||||
| Cori Cycle | |||||
| Hexose transport | |||||
| Type II diabetes mellitus | |||||
| AMPK Signaling | |||||
| References | |||||
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