Target Information

Target General Infomation
Target ID
T77195
Former ID
TTDS00469
Target Name
NADH dehydrogenase
Gene Name
MT-ND3
Synonyms
MT-ND; MTND; NADH; NADH-ubiquinone oxidoreductase; ND; MT-ND3
Target Type
Successful
Disease Parkinson's disease [ICD9: 332; ICD10: G20]
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
BioChemical Class
Oxidoreductases acting on NADH or NADPH
Target Validation
T77195
UniProt ID
P03897
EC Number
EC 1.6.5.3
Sequence
MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAI
TFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWTE
Drugs and Mode of Action
Drug(s) NADH Drug Info Approved Parkinson's disease [467727], [550734]
Inhibitor 6-Thiophen-2-yl-imidazo[2,1-b]thiazole Drug Info [533704]
6-Thiophen-3-yl-imidazo[2,1-b]thiazole Drug Info [533704]
N-Formylmethionine Drug Info [551393]
Binder NADH Drug Info [535889]
Pathways
KEGG Pathway Oxidative phosphorylation
Metabolic pathways
Parkinson&#039
s disease
WikiPathways Oxidative phosphorylation
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Electron Transport Chain
References
Ref 467727(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4487).
Ref 550734Drug information of NADH, 2008. eduDrugs.
Ref 533704J Med Chem. 1995 Mar 31;38(7):1090-7.Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase.
Ref 535889Mechanism of cadmium-decreased glucuronidation in the rat. Biochem Pharmacol. 1992 Dec 1;44(11):2139-47.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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