Target Information

Target General Infomation
Target ID
T85158
Former ID
TTDC00327
Target Name
Lymphotoxin alpha
Gene Name
LTA
Synonyms
LT-alpha; Lymphotoxin-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; LTA
Target Type
Clinical Trial
Disease Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumorcells in vitro and in vivo.
BioChemical Class
Cytokine: tumor necrosis factor
UniProt ID
P01374
Sequence
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
LSTHTDGIPHLVLSPSTVFFGAFAL
Drugs and Mode of Action
Drug(s) Anti-LT alpha Drug Info Phase 2 Rheumatoid arthritis [550794]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
TNF signaling pathway
Type I diabetes mellitus
HTLV-I infection
Herpes simplex infection
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database IL4-mediated signaling events
IL2 signaling events mediated by STAT5
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Apoptosis
References
Ref 550794Clinical pipeline report, company report or official report of Genentech (2011).
Ref 550794Clinical pipeline report, company report or official report of Genentech (2011).

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