Target Information

Target General Infomation
Target ID
T92030
Former ID
TTDNC00443
Target Name
Human pro-islet peptide
Gene Name
REG3A
Synonyms
HIP/PAP; Hepatointestinal pancreatic protein; Human proislet peptide; Pancreatitis-associated protein 1; REG-3-alpha; Reg III-alpha; Regenerating islet-derived protein 3-alpha; Regenerating islet-derived protein 3-alpha 15 kDa form; Regenerating islet-derived protein III-alpha; REG3A
Target Type
Clinical Trial
Disease Liver failure [ICD10: K72.9]
Type 1/2 diabetes [ICD9: 250, 278; ICD10: E08-E13]
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
BioChemical Class
Regiii family
UniProt ID
Q06141
Sequence
MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS
WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW
EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD
Drugs and Mode of Action
Drug(s) ALF-5755 Drug Info Phase 2 Liver failure [523402]
HIP-2B Drug Info Phase 1 Type 1/2 diabetes [524417]
Modulator ALF-5755 Drug Info [544450]
HIP-2B Drug Info [525626]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
References
Ref 523402ClinicalTrials.gov (NCT01318525) Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure. U.S. National Institutes of Health.
Ref 524417ClinicalTrials.gov (NCT01933256) Study of Subcutaneous Doses of HIP2B in Subjects With Type 2 Diabetes Mellitus Treated With Metformin. U.S. National Institutes of Health.
Ref 525626Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Am J Pathol.1999 Nov;155(5):1525-33.
Ref 544450HIP/PAP prevents excitotoxic neuronal death and promotes plasticity. Ann Clin Transl Neurol. 2014 October; 1(10): 739-754.

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