Target Information

Target General Infomation
Target ID
T94324
Former ID
TTDR01338
Target Name
Histone Deacetylase 10
Gene Name
HDAC10
Synonyms
HDAC10
Target Type
Research
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Target Validation
T94324
UniProt ID
Q969S8
Sequence
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
Inhibitor (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Drug Info [1]
2-(methylsulfonylthio)ethyl 2-propylpentanoate Drug Info [2]
4-Benzoylamino-N-hydroxy-benzamide Drug Info [3]
4-Butyrylamino-N-hydroxy-benzamide Drug Info [4]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Drug Info [5]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Drug Info [6]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Drug Info [5]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Drug Info [7]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Drug Info [2]
5-Mercapto-pentanoic acid phenylamide Drug Info [6]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Drug Info [6]
6-benzenesulfinylhexanoic acid hydroxamide Drug Info [8]
6-benzenesulfonylhexanoic acid hydroxamide Drug Info [8]
6-Mercapto-hexanoic acid phenylamide Drug Info [6]
6-Phenoxy-hexane-1-thiol Drug Info [6]
6-phenylsulfanylhexanoic acid hydroxamide Drug Info [8]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Drug Info [1]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Drug Info [9]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Drug Info [1]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Drug Info [1]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide Drug Info [6]
7-Mercapto-heptanoic acid biphenyl-3-ylamide Drug Info [6]
7-Mercapto-heptanoic acid biphenyl-4-ylamide Drug Info [6]
7-Mercapto-heptanoic acid phenylamide Drug Info [6]
7-Mercapto-heptanoic acid pyridin-3-ylamide Drug Info [6]
7-Mercapto-heptanoic acid quinolin-3-ylamide Drug Info [6]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Drug Info [1]
8-Mercapto-octanoic acid phenylamide Drug Info [6]
8-Oxo-8-phenyl-octanoic acid Drug Info [5]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Drug Info [9]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Drug Info [9]
Cyclostellettamine derivative Drug Info [10]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Drug Info [11]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Drug Info [11]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Drug Info [5]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide Drug Info [5]
N-(6-Mercapto-hexyl)-benzamide Drug Info [6]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Drug Info [3]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Drug Info [3]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Drug Info [3]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Drug Info [3]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Drug Info [3]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Drug Info [3]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Drug Info [4]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Drug Info [4]
N-Hydroxy-4-phenylacetylamino-benzamide Drug Info [3]
Octanedioic acid hydroxyamide pyridin-2-ylamide Drug Info [5]
Octanedioic acid hydroxyamide pyridin-4-ylamide Drug Info [5]
PSAMMAPLIN A Drug Info [9]
ST-2986 Drug Info [12]
ST-2987 Drug Info [12]
ST-3050 Drug Info [12]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Drug Info [6]
Pathways
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
References
REF 1Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13.Heterocyclic ketones as inhibitors of histone deacetylase.
REF 2Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. Epub 2008 Feb 8.New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.
REF 3J Med Chem. 2005 Aug 25;48(17):5530-5.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.
REF 4J Med Chem. 2004 Jan 15;47(2):467-74.Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.
REF 5J Med Chem. 2002 Feb 14;45(4):753-7.Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
REF 6J Med Chem. 2005 Feb 24;48(4):1019-32.Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.
REF 7Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.
REF 8J Med Chem. 2006 Jan 26;49(2):800-5.Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides.
REF 9J Med Chem. 2003 Nov 20;46(24):5097-116.Histone deacetylase inhibitors.
REF 10Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.
REF 11Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors.
REF 12Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. Epub 2009 Feb 12.N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC)inhibitors.

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