Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T96014
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| Former ID |
TTDR00662
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| Target Name |
UDP-glucose 4-epimerase
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| Gene Name |
GALE
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| Synonyms |
Galactowaldenase; UDP-galactose4'-epimerase; UDP-galactose4-epimerase; GALE
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| Target Type |
Research
|
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| Function |
Catalyzes twodistinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
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| BioChemical Class |
Racemases and epimerases
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| Target Validation |
T96014
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| UniProt ID | |||||
| EC Number |
EC 5.1.3.2
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| Sequence |
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA |
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| Inhibitor | Glucose-Uridine-C1,5'-Diphosphate | Drug Info | [1] | ||
| Nicotinamide-Adenine-Dinucleotide | Drug Info | [1] | |||
| Phenyl-Uridine-5'-Diphosphate | Drug Info | [1] | |||
| PSAMMAPLIN A | Drug Info | [2] | |||
| Tetramethylammonium Ion | Drug Info | [1] | |||
| Uridine Diphosphate Galactose | Drug Info | [3] | |||
| Uridine-5'-Diphosphate | Drug Info | [1] | |||
| Uridine-5'-Diphosphate-Mannose | Drug Info | [1] | |||
| Uridine-Diphosphate-N-Acetylgalactosamine | Drug Info | [1] | |||
| Uridine-Diphosphate-N-Acetylglucosamine | Drug Info | [4] | |||
| Pathways | |||||
| BioCyc Pathway | D-galactose degradation V (Leloir pathway) | ||||
| UDP-N-acetyl-D-galactosamine biosynthesis I | |||||
| UDP-N-acetyl-D-galactosamine biosynthesis II | |||||
| KEGG Pathway | Galactose metabolism | ||||
| Amino sugar and nucleotide sugar metabolism | |||||
| Metabolic pathways | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Fructose galactose metabolism | ||||
| PathWhiz Pathway | Nucleotide Sugars Metabolism | ||||
| Galactose Metabolism | |||||
| WikiPathways | Metabolism of carbohydrates | ||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7. Epub 2006 Sep 7.Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. | ||||
| REF 3 | Crystal structure of beta1,4-galactosyltransferase complex with <span class="caps">UDP</span>-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502. | ||||
| REF 4 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
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