Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00CRA
|
||||
| Former ID |
DIB018566
|
||||
| Drug Name |
2-methyl-5-HT
|
||||
| Synonyms |
2-methyl-5-hydroxytryptamine; 2-Me-5-HT; 2-methylserotonin
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C11H14N2O
|
||||
| InChI |
InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
|
||||
| InChIKey |
WYWNEDARFVJQSG-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
586258, 5622994, 7979274, 8151190, 11111405, 11113566, 15195322, 24439900, 26751773, 46530587, 47217001, 47440490, 47515543, 47662518, 48035361, 49984687, 50104460, 53787855, 57320945, 74480832, 85208910, 90341641, 103165526, 103926391, 104298110, 117405325, 124750022, 124880617, 124880618, 124880619, 126407134, 129654269, 134340782, 135065522, 135649706, 137005044, 137187665, 162219629, 172881028, 179235689, 218920442, 223551136, 226727709, 249555206, 249767827, 252214306, 252426195
|
||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine receptor 3A | Target Info | Agonist | [2] | |
| 5-hydroxytryptamine 1B receptor | Target Info | Agonist | [3] | ||
| 5-HT3AB | Target Info | Agonist | [4] | ||
| 5-hydroxytryptamine 1F receptor | Target Info | Agonist | [5] | ||
| 5-hydroxytryptamine 1E receptor | Target Info | Agonist | [5] | ||
| 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [6] | ||
| 5-hydroxytryptamine 6 receptor | Target Info | Agonist | [7] | ||
| 5-hydroxytryptamine 2B receptor | Target Info | Agonist | [8] | ||
| KEGG Pathway | Serotonergic synapsehsa04024:cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | 5HT3 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Ligand-gated ion channel transportR-HSA-390666:Serotonin receptors | ||||
| G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (q) signalling events | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Iron uptake and transportWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
| GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 218). | ||||
| REF 2 | Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409(2):195-201. | ||||
| REF 3 | Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. | ||||
| REF 4 | The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63. | ||||
| REF 5 | Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. | ||||
| REF 6 | Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. | ||||
| REF 7 | Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology. 1997 Apr-May;36(4-5):713-20. | ||||
| REF 8 | Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.