Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T60914
|
||||
| Former ID |
TTDI03003
|
||||
| Target Name |
5-HT3AB
|
||||
| Target Type |
Research
|
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| Antagonist | (S)-zacopride | Drug Info | [1] | ||
| [3H]granisetron | Drug Info | [1] | |||
| Agonist | 1-phenylbiguanide | Drug Info | [1] | ||
| 2-methyl-5-HT | Drug Info | [2] | |||
| meta-chlorphenylbiguanide | Drug Info | [1] | |||
| Blocker (channel blocker) | bilobalide | Drug Info | [3] | ||
| Modulator (allosteric modulator) | trichloroethanol | Drug Info | [4] | ||
| References | |||||
| REF 1 | Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. | ||||
| REF 2 | The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63. | ||||
| REF 3 | Ginkgolide B and bilobalide block the pore of the 5-HT??eceptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb-Mar;60(2-3):488-95. | ||||
| REF 4 | Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. Epub 2005 Oct 28. | ||||
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