Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B0TK
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| Former ID |
DIB018976
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| Drug Name |
bilobalide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C15H18O8
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| InChI |
InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
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| InChIKey |
MOLPUWBMSBJXER-YDGSQGCISA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
612782, 8195779, 16291978, 22401403, 26754286, 26754287, 43129494, 48483982, 50066930, 50356007, 57319167, 72294694, 85756505, 92465249, 99319068, 103068082, 103083126, 104355597, 119525292, 124558739, 124791097, 135652670, 136198417, 137140610, 141417239, 162187986, 162220494, 163614295, 175607715, 179326410, 184546819, 184812239, 198968270, 204379274, 210280216, 210282195, 223567071, 223668098, 223701049, 226629534, 241062586, 241201449, 242132532, 249865353, 252063817, 252216667, 252345969
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| Target and Pathway | |||||
| Target(s) | 5-HT3AB | Target Info | Blocker (channel blocker) | [2] | |
| 5-hydroxytryptamine receptor 3A | Target Info | Blocker (channel blocker) | [3] | ||
| Glycine Receptor (All subtypes) | Target Info | [4] | |||
| Glycine receptor | Target Info | Antagonist | [5] | ||
| KEGG Pathway | Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | 5HT3 type receptor mediated signaling pathway | ||||
| Reactome | Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Iron uptake and transportWP2670:Iron uptake and transport | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2366). | ||||
| REF 2 | Ginkgolide B and bilobalide block the pore of the 5-HT??eceptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb-Mar;60(2-3):488-95. | ||||
| REF 3 | Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Mol Pharmacol. 2011 Jul;80(1):183-90. | ||||
| REF 4 | Molecular determinants of ginkgolide binding in the glycine receptor pore. J Neurochem. 2006 Jul;98(2):395-407. | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 427). | ||||
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