Drug General Information
Drug ID	D00EPD
Former ID	DNC003671
Drug Name	6-(2-Chloro-benzenesulfonyl)-2H-pyridazin-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527771]
Structure		Download 2D MOL 3D MOL
Formula	C10H7ClN2O3S
Canonical SMILES	C1=CC=C(C(=C1)S(=O)(=O)C2=NNC(=O)C=C2)Cl
InChI	1S/C10H7ClN2O3S/c11-7-3-1-2-4-8(7)17(15,16)10-6-5-9(14)12-13-10/h1-6H,(H,12,14)
InChIKey	FTLDTGWMVVXYAM-UHFFFAOYSA-N
PubChem Compound ID	9921581
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[527771]
BioCyc Pathway	Methylglyoxal degradation III
	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 527771	J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Ref 527771	J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

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