Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00HVZ
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| Former ID |
DNC007437
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| Drug Name |
(+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one
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| Synonyms |
7-methoxy-2-(4-methoxyphenyl)chroman-4-one
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| Indication | Discovery agent | Investigative | [530614] | ||
| Structure |
|
Download2D MOL |
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| Canonical SMILES |
COC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(C=C3)OC
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| InChI |
1S/C17H16O4/c1-19-12-5-3-11(4-6-12)16-10-15(18)14-8-7-13(20-2)9-17(14)21-16/h3-9,16H,10H2,1-2H3
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| InChIKey |
YAEYGSBLDUIDTP-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Cytochrome P450 19 | Target Info | Inhibitor | [528848] | |
| Amine oxidase [flavin-containing] B | Target Info | Inhibitor | [530614] | ||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolic pathways | |||||
| Ovarian steroidogenesishsa00260:Glycine, serine and threonine metabolism | |||||
| Arginine and proline metabolism | |||||
| Histidine metabolism | |||||
| Tyrosine metabolism | |||||
| Phenylalanine metabolism | |||||
| Tryptophan metabolism | |||||
| Drug metabolism - cytochrome P450 | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
| Reactome | Endogenous sterols | ||||
| WikiPathways | Metapathway biotransformation | ||||
| Tryptophan metabolism | |||||
| Oxidation by Cytochrome P450 | |||||
| Ovarian Infertility Genes | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| FSH signaling pathway | |||||
| Integrated Breast Cancer Pathway | |||||
| Phase 1 - Functionalization of compoundsWP465:Tryptophan metabolism | |||||
| Dopamine metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| Ref 528848 | J Med Chem. 2007 Jun 14;50(12):2799-806. Epub 2007 May 19.Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. | ||||
| Ref 530614 | Bioorg Med Chem. 2010 Feb;18(3):1273-9. Epub 2010 Jan 4.A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. | ||||
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