Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00IXN
|
||||
| Former ID |
DIB008861
|
||||
| Drug Name |
GS-6637
|
||||
| Indication | Substance dependence [ICD10:F10-F19] | Phase 1 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Target and Pathway | |||||
| Target(s) | Aldehyde dehydrogenase, mitochondrial | Target Info | Inhibitor | [2], [3] | |
| KEGG Pathway | Glycolysis / Gluconeogenesis | ||||
| Pentose and glucuronate interconversions | |||||
| Ascorbate and aldarate metabolism | |||||
| Fatty acid degradation | |||||
| Valine, leucine and isoleucine degradation | |||||
| Lysine degradation | |||||
| Arginine and proline metabolism | |||||
| Histidine metabolism | |||||
| Tryptophan metabolism | |||||
| beta-Alanine metabolism | |||||
| Glycerolipid metabolism | |||||
| Pyruvate metabolism | |||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| PathWhiz Pathway | Beta-Alanine Metabolism | ||||
| Ethanol Degradation | |||||
| Histidine Metabolism | |||||
| Valine, Leucine and Isoleucine Degradation | |||||
| Pyruvate Metabolism | |||||
| Oxidation of Branched Chain Fatty Acids | |||||
| Glycine and Serine Metabolism | |||||
| Tryptophan Metabolism | |||||
| WikiPathways | Tryptophan metabolism | ||||
| Fatty Acid Omega Oxidation | |||||
| Phase 1 - Functionalization of compounds | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040688) | ||||
| REF 2 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
| REF 3 | Clinical pipeline report, company report or official report of Gilead. | ||||
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