| Drug General Information |
| Drug ID |
D00LHS
|
| Former ID |
DNC006894
|
| Drug Name |
TW-37
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C33H35NO6S
|
| Canonical SMILES |
CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=<br />O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O
|
| InChI |
1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)
|
| InChIKey |
PQAPVTKIEGUPRN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Apoptosis regulator Bcl-2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 |
Target Info |
Inhibitor |
[1]
|
| mRNA of Bcl-x |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
NF-kappa B signaling pathway
|
|
HIF-1 signaling pathway
|
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Sphingolipid signaling pathway
|
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Protein processing in endoplasmic reticulum
|
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PI3K-Akt signaling pathway
|
|
Apoptosis
|
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Adrenergic signaling in cardiomyocytes
|
|
Focal adhesion
|
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Neurotrophin signaling pathway
|
|
Cholinergic synapse
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Toxoplasmosis
|
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Tuberculosis
|
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Hepatitis B
|
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Epstein-Barr virus infection
|
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Pathways in cancer
|
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MicroRNAs in cancer
|
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Colorectal cancer
|
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Prostate cancer
|
|
Small cell lung cancerhsa04151:PI3K-Akt signaling pathway
|
|
MicroRNAs in cancerhsa04014:Ras signaling pathway
|
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Jak-STAT signaling pathway
|
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HTLV-I infection
|
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Transcriptional misregulation in cancer
|
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Pancreatic cancer
|
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Chronic myeloid leukemia
|
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Small cell lung cancer
|
|
NetPath Pathway
|
IL5 Signaling Pathway
|
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TCR Signaling Pathway
|
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IL2 Signaling Pathway
|
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IL3 Signaling Pathway
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Leptin Signaling Pathway
|
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RANKL Signaling Pathway
|
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TSLP Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
Notch Signaling Pathway
|
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PANTHER Pathway
|
Apoptosis signaling pathway
|
|
Oxidative stress response
|
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CCKR signaling map STP00006:Apoptosis signaling pathway
|
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CCKR signaling map ST
|
|
Pathway Interaction Database
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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IL2-mediated signaling events
|
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IL2 signaling events mediated by PI3K
|
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Ceramide signaling pathway
|
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Direct p53 effectors
|
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RXR and RAR heterodimerization with other nuclear receptor
|
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ATF-2 transcription factor network
|
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C-MYB transcription factor network
|
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
|
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Caspase Cascade in Apoptosis
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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EPO signaling pathway
|
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IL2 signaling events mediated by STAT5
|
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Validated targets of C-MYC transcriptional repressione2f_pathway:E2F transcription factor network
|
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IL6-mediated signaling events
|
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HIF-1-alpha transcription factor networkil2_pi3kpathway:IL2 signaling events mediated by PI3K
|
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IL3-mediated signaling events
|
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Reactome
|
Activation of BAD and translocation to mitochondria
|
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BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
|
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The NLRP1 inflammasomeR-HSA-111453:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
|
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The NLRP1 inflammasome
|
|
WikiPathways
|
DNA Damage Response (only ATM dependent)
|
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Senescence and Autophagy in Cancer
|
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IL-2 Signaling Pathway
|
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FAS pathway and Stress induction of HSP regulation
|
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Focal Adhesion
|
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Kit receptor signaling pathway
|
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IL-3 Signaling Pathway
|
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Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
|
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Apoptosis
|
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Nanoparticle triggered autophagic cell death
|
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Amyotrophic lateral sclerosis (ALS)
|
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Integrated Pancreatic Cancer Pathway
|
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Corticotropin-releasing hormone
|
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Interleukin-11 Signaling Pathway
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Prostate Cancer
|
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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Integrated Breast Cancer Pathway
|
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Integrated Cancer pathway
|
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Intrinsic Pathway for Apoptosis
|
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Apoptosis Modulation and Signaling
|
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TP53 Network
|
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Influenza A virus infection
|
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IL-5 Signaling PathwayWP254:Apoptosis
|
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Apoptosis Modulation and SignalingWP364:IL-6 signaling pathway
|
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TNF alpha Signaling Pathway
|
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IL-7 Signaling Pathway
|
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Leptin signaling pathway
|
| References |
| REF 1 | J Med Chem. 2006 Oct 19;49(21):6139-42.Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. |
|---|
| REF 2 | J Med Chem. 2010 Mar 25;53(6):2577-88.Fragment-based deconstruction of Bcl-xL inhibitors. |
|---|
